Career page Career page
.
All topics also are in the ‘Theories’ page.
The start was an assignment to model the
facilitated diffusion
of oxygen (O2) through flat layers containing
hemoglobin (Hb).
This resulted in a paper published 1970 and an appointment to the Department of
Physiology of the Nijmegen University. There, my job was to work together with
the other scientists in solving the physical/mathematical and computer aspects.
Consequently, the topics below refer to treatments from a modelling and
theoretical standpoint; supplementary to what is found in textbooks. Click the
icon for the respective
page.
Theoretical treatment of carrier-assisted diffusion in flat layers.
Originally, this was about O2 and Hb but evolved including
CO2, CO, ion diffusion and electrical potentials,
myoglobin (Mb),
and a general mathematical treatment. Also, simultaneous tissue oxygen
consumption was considered.
The role of hemoglobin (Hb), within the red blood cell, in the oxygen transport
in the body. Both the binding and release properties as well as the
consequences of being contained in only part of the moving blood, in a cell.
Modelling of
alveolar
oxygen tension
as result of lung functioning. Later, this led to a complete computer
model of breathing used in the students course.
Evaluation and results of measurements in a
diffusion chamber,
a device where gases pass through an inert or reacting or tissue layer.
Modelling of oxygen transport in muscle tissue, including the release
from (parallel)
capillaries
and reaction with other species, in particular
myoglobin (Mb).
Domain
method, to evaluate capillary
distribution
in a tissue and the relation with other
structures, like cells. Following, a complete statistical treament was worked out.
Blood circulation model, for the human body, including regulations.
Purpose was to validate a non-invasive method to predict pulmonary capillary
wedge pressure
in elderly patients but the human body turned out to be far too complicated for that.
In simplified form it was used in student education.
Evaluation of Near InfraRed Spectroscopy (NIRS) in terms of tissue
oxygen. It is an easy, non-invasive and ultrafast method to measure blood
oxgyenation
and its distribution.
